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    Advances in basic immunology have translated into new, more complex therapeutic strategies.The findings from current trials and the demonstrated potential to combine vaccines with conventional therapies herald a promising future for the treatment of prostate cancer.

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    ”Anesthesiologist and LASIK patient“Growing up, my favorite activities were boating and waterskiing.Over the last two decades many new immunotherapy approaches to the treatment of cancer have entered clinical development due to the increased understanding of the mechanisms of antigen presentation, lymphocyte recognition, functions of the innate immune system, and the means of regulation of these responses and the means by which tumors can circumvent these responses.Many of these investigations have led to agents approved for standard clinical use, including infusional cytokine therapies for melanoma or renal cell cancer, intravesical BCG therapy for bladder cancer, and most recently an active cellular therapy targeting prostatic acid phosphatase (PAP, sipuleucel-T, Provenge, Dendreon) for patients with advanced metastatic prostate cancer.We found that different antigens were recognized following androgen deprivation compared with vaccine therapies.While the number of clinical responders was low in the vaccine-treated populations, we demonstrate that ML-BBN can be used to develop potentially predictive models.

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